Wayne State University

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Jessica Damoiseaux

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Bio Sketch

Jessica Damoiseaux, Ph.D., is an Assistant Professor in the Institute of Gerontology and the Department of Psychology. Dr. Damoiseaux' main research goal is to understand the changes in brain function and cognition that accompany normal and abnormal aging. She is particularly interested in examining the influence of biological and cognitive predisposition on cognitive and brain network connectivity changes in healthy older adults. The primary approach Dr. Damoiseaux uses to study brain network connectivity is functional magnetic resonance imaging (fMRI). In addition, she uses other neuroimaging techniques, such as structural MRI and diffusion tensor imaging (DTI) to study brain structure and structural brain connectivity.

Research Focus

 Dr. Damoiseaux's main research project is a longitudinal aging study, in which she collects neuroimaging data, genetics and neuropsychological data of healthy older adults. This study will allow her to investigate age-related changes in brain function and cognitive function, and the effect of biological and cognitive background on age-related changes within subjects.

Another project examines the differences in brain function between older adults with subjective cognitive impairment (SCI) and healthy older adults, and assesses the changes in brain function within these groups over time. The aim of this study is to examine whether SCI is a precursor of Alzheimer's disease (AD). SCI is a common condition in which a patient has memory complaints but no deficits on formal cognitive testing. Unlike amnestic mild cognitive impairment (MCI), which is widely recognized as a precursor of AD, it is still unclear whether SCI is a forerunner of AD, representing the latent phase of the disease.
Areas of Expertise

Neuroimaging, Resting State fMRI, Functional Connectivity, Aging, Neurodegenerative Disease. 

Education

PhD in Cognitive Neuroscience (2008)
VU University Medical Center, Amsterdam, the Netherlands.

M.Sc. in Psychology (2003)
Utrecht University, Utrecht, the Netherlands

Training

Postdoctoral research fellow, April 2008 - March 2013
Stanford School of Medicine, Stanford, CA
Department of Neurology and Neurological sciences
Functional Imaging in Neuropsychiatric Disorders (FIND) Laboratory

Studied brain network plasticity and the effect of genes on brain function in healthy aging, neurological and psychiatric patient populations. PI: Michael Greicius MD.
 

Grants

VENI grant from the Netherlands Organization for Scientific Research (2/1/2013 - 2/1/2017)
Project title: Subjective cognitive impairment: a sign of incipient Alzheimer's disease? A longitudinal study of functional and structural brain changes in healthy older adults with and without cognitive complaints.

Publications
  • Damoiseaux JS, Huijbers W. The complementary value of task-evoked and resting-state functional imaging: a commentary on Campbell and Schacter (2016). Language, Cognition and Neuroscience. 2016 Oct 25:1-3.
  • Damoiseaux JS, Viviano RP, Yuan P, Raz N. Differential effect of age on posterior and anterior hippocampal functional connectivity. NeuroImage. 2016 Jun 30;133:468-76.
  • White MP, Shirer WR, Molfino MJ, Tenison C, Damoiseaux JS, Greicius MD. Disordered reward processing and functional connectivity in trichotillomania: a pilot study. Journal of psychiatric research. 2013 Sep 30;47(9):1264-72
  • Damoiseaux JS, Seeley WW, Zhou J, Shirer WR, Coppola G, Karydas A, Rosen HJ, Miller, BL, Kramer JH, Greicius MD. Gender Modulates the APOE ε4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels. J. NeuroSci. 2012 Jun 13;32(24):8254-8262.
  • Damoiseaux JS. Resting-state fMRI as a biomarker for Alzheimer's disease? Alzheimers Res Ther. 2012 Mar 15;4(3):8.
  • Binnewijzend MA, Schoonheim MM, Sanz-Arigita E, Wink AM, van der Flier WM, Tolboom N, Adriaanse SM, Damoiseaux JS, Scheltens P, van Berckel BN, Barkhof F. Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging. 2012 Sep;33(9):2018-28. Epub 2011 Aug 20.
  • Damoiseaux JS, Prater K, Miller BL, Greicius MD. Functional connectivity tracks clinical deterioration in Alzheimer's disease. Neurobiol Aging. 2012 Apr;33(4):828.e19-30. Epub 2011 Aug 16.
  • Sanz-Arigita EJ, Schoonheim MM, Damoiseaux JS, Rombouts SA, Maris E, Barkhof F, Scheltens P, Stam CJ. Loss of 'small-world' networks in Alzheimer's disease: graph analysis of FMRI resting-state functional connectivity. PLoS One. 2010 Nov 1;5(11):e13788.
  • Zarei M, Patenaude B, Damoiseaux J, Morgese C, Smith S, Matthews PM, Barkhof F, Rombouts S, Sanz-Arigita E, Jenkinson M. Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease. Neuroimage. 2010 Jan 1;49(1):1-8.
  • Damoiseaux JS, Greicius MD. Greater Than the Sum of Its Parts: A Review of Studies Combining Structural Connectivity and Resting-State Functional Connectivity. Brain Struct Funct. 2009 Oct;213(6):525-33. Epub 2009 Jun 30.
  • Zarei M, Damoiseaux JS, Morgese C, Beckmann CF, Smith SM, Matthews PM, Scheltens P, Rombouts SA, Barkhof F. Regional White Matter Integrity Differentiates between Vascular Dementia and Alzheimer's Disease. Stroke. 2009 Mar;40(3):773-9. Epub 2009 Jan 22.
  • Damoiseaux JS, Smith SM, Witter MP, Sanz-Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Zarei M, Rombouts SA. White matter tract integrity in aging and Alzheimer's disease. Hum Brain Mapp. 2009 Apr;30(4):1051-9.
  • Rombouts SA, Damoiseaux JS, Goekoop R, Barkhof F, Scheltens P, Smith SM, Beckmann CF. Model-free group analysis shows altered BOLD FMRI networks in dementia. Hum Brain Mapp. 2009 Jan;30(1):256-66.
  • Damoiseaux JS, Beckmann CF, Sanz-Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Smith SM, Rombouts SA. Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex. 2008 Aug;18(8):1856-64.
  • Oei NY, Elzinga BM, Wolf OT, de Ruiter MB, Damoiseaux JS, Kuijer JP, Veltman DJ, Scheltens P, Rombouts SA. Glucocorticoids decrease hippocampal and prefrontal activation during declarative memory retrieval in young men. Brain Imaging Behav. 2007 Jun;1(1-2):31-41. Epub 2007 Jun 1.
  • Damoiseaux JS, Rombouts SA, Barkhof F, Scheltens P, Stam CJ, Smith SM, Beckmann CF. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53.